What is liver disease? What is pancreatic cancer? What are liver tumors

How do I get treatment?

For further information and appointments please see the below contact numbers:

For Mr Rob Hutchins:

020 7234 2940

For the following Consultants:

020 7234 2730

Professor Nigel Heaton
Mr Parthi Srinivasan
Mr Andreas A. Prachalias
Dr Phil M. Harrison
Dr Michael Heneghan

London HCC Treatment

Options for Treatment of Hepatocellular Carcinoma in London

There are a number of treatments for HCC available to patients, depending on how extensive the disease is both within the liver and if it has spread outside the liver, the patients general health, in particular the condition of the patient’s background liver, and age. The following treatment options are available:

Surgery as a treatment for HCC (Hepatocellular Carcinoma)

Surgery is the most effective treatment for primary liver cancer, but this is not always possible due to the size or position of the tumour. It is also not possible to operate if the cancer has spread beyond the liver. If the liver is severely damaged by cirrhosis it may not be safe to have surgery.
The liver has an amazing ability to repair itself. Even if up to three-quarters of the liver is removed it will start to re-grow very quickly, and may be back to normal size within a few weeks.
Before any operation, you will have the opportunity to discuss this completely and frankly with your Consultant so that you understand exactly what it involves. If only certain areas of the liver are affected by the cancer and the rest of the liver is healthy, it may be possible to have an operation to remove the affected part this is called a liver resection.

Liver transplantation as a treatment for HCC

Liver transplantation is recognised as the most effective potentially curative treatment.
Removing the whole liver and replacing it with a liver from another person is a HCC treatment, but can only be done in those cases when the tumour is small (less than 5cm) or there are fewer than three tumours, all smaller than 3cm in size.
The London Liver Centre offers Living Donor Liver Transplantation (where a relative will donate part of their liver to the recipient) as part of its comprehensive clinical programme.

Loco-regional therapy as a HCC treatment

This is offered if:

• We are not able to offer you either liver surgery or transplantation
• As a first step in a treatment programme which will include liver surgery
• As a ‘holding treatment’ while you are on the waiting list for liver transplantation

These procedures are not a cure for liver cancer. However, studies have shown that many patients experience an improvement in symptoms and quality of life. They may also slow or halt further growth of the tumour.

The therapies are:

Trans-arterial chemo-embolisation (TACE)

Chemotherapy is delivered directly into the area of the liver that contains the cancer and this is followed by the injection of a substance that blocks the small blood vessels feeding the tumour (embolisation).

Some patients are not able to tolerate the chemotherapy drug used in TACE, but would benefit from the embolisation of the blood vessels feeding the tumour. In this situation, we can also offer embolisation without the chemotherapy drug Trans-arterial embolisation (TAE)

Radio-frequency ablation (RFA)

Radiofrequency ablation (RFA) is used to obliterate tumours of the liver. A low electrical current is passed through the tumour tissue, generating heat so that the tumour cells die.

Sorafenib as a HCC Treatment

Sorafenib is a drug, taken as a tablet. It slows down the growth of cancer cells by stopping the signals that tell the cancer cells to grow and multiply and it also helps to prevent the growth of new blood vessels supplying the cancer. This will reduce the amount of oxygen and nutrients the tumour can receive and interfere with its growth.

Systemic chemotherapy for treatment of HCC

Systemic chemotherapy, where you are given drugs which kill cancer cells via a drip in your arm, is rarely used for the treatment of HCC as it has little effect on the disease.

Radiotherapy for HCC

Radiotherapy is not used to treat HCC as it has no proven beneficial effect in this disease.